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Nat Commun. Activation of Jun kinase is an early event in hepatic regeneration. JCI Insight. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. J Gastroenterol. 2011 Jul; 41(7):683-6. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2011 Jan; 53(1):96-105. Gastroenterology. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. 2020 05; 72(5):946-959. J Clin Invest. J Clin Gastroenterol. Front Physiol. 2009 Jan 16; 378(3):348-53. Nat Med. 2020; 15(3):e0229445. 2003 Oct; 23(5):386-96. Hepatology. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. 2014 Jul 21; 5:4451. Dig Liver Dis. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. 2003 May; 73(1):44-52. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. 1990 Jun; 11(6):909-15. Am J Physiol Cell Physiol. 2020 Nov 03; 32(5):901. Hepatology. J Biol Chem. Hepatol Commun. 1994 Oct 21; 269(42):26396-401. Analysis of the collagen alpha 1(I) promoter. Hepatology. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 1998 09; 275(3):G387-92. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Am J Physiol Cell Physiol. 2013 02 15; 177(4):333-42. 2003 Apr; 37(4):824-32. 2021 08 01; 321(2):H435-H445. 1991 12; 54(6 Suppl):1141S-1143S. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. 1999 Aug; 21(2):238-45. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. 2018 09; 68(3):918-932. Dig Dis Sci. 2016 Sep; 92(3):84-92. 2017 09 15; 331:135-141. Gastroenterology. 2017 Apr 03; 127(4):1254-1270. Blood. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Hepatology. 2005 Jul 29; 280(30):27879-87. Quadruple genetic variants in a sporadic ALS patient. 1998 Sep; 13 Suppl:S39-50. Signal transduction during liver regeneration. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Cancer Res. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Gastroenterology. 1997 10; 273(4):G795-803. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. 1991; 10(3-4):452-5. Aliment Pharmacol Ther. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. DNA Cell Biol. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. 1989 May; 9(5):2224-7. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2018 12; 16(12):1974-1982.e7. Gut. 2020 05; 158(6):1728-1744.e14. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. In this role, he leads the School of Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. Recent advancement of molecular mechanisms of liver fibrosis. 2005 Sep 16; 335(1):87-96. Reversibility of liver fibrosis. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Adv Second Messenger Phosphoprotein Res. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Am J Physiol Gastrointest Liver Physiol. 2011 May; 53(5):1730-41. J Biol Chem. Nat Med. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Semin Liver Dis. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 2015 Apr; 61(4):1239-50. Cell Metab. 2019 02 04; 216(2):267-278. 2003 Mar; 37(3):653-64. 2006 Aug; 44(2):420-9. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Genomics of liver fibrosis and cirrhosis. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Hepatology. Cancer Res. FASEB J. 2015 Jan; 22(1):164-73. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Nat Immunol. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. FASEB J. 2018 12; 15(12):785. J Clin Invest. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 1987 Sep; 79(3):449-56. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 2007 Dec; 52(12):3404-15. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 2016 Feb; 43(2):179-87. 2010 Feb 25; 3:39-47. 2001 Jan; 280(1):G139-48. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. Gastroenterology. 2017 11; 15(11):1808-1810. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Front Mol Biosci. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Mol Cell Biol. Analysis of the human ferrochelatase promoter in transgenic mice. Hum Gene Ther. 2014 Jul; 124(7):2921-34. 2008 Dec; 173(6):1617-27. Am J Physiol Gastrointest Liver Physiol. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Am J Physiol Gastrointest Liver Physiol. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Proc Natl Acad Sci U S A. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. 2015 Sep; 39 Suppl 1:S75-9. Cell Metab. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. 2005 Feb; 115(2):209-18. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Alzheimer's disease: the vascular connection. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. To return to the graph. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2022 09; 609(7925):101-108. Am J Respir Cell Mol Biol. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. 2003 Jan 01; 8:d69-77. Cell Metab. 2009 Sep; 50(3):929-38. Sp1 binding activity increases in activated Ito cells. 2019 03; 156(4):1156-1172.e6. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. 2001 Jun 01; 166(11):6812-9. 2005 Apr 08; 280(14):13374-82. Hepatology. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 1995; 255:342-59. J Hepatol. Am J Physiol. Hepatology. 1992 Jul-Aug; 11(6):443-52. Hepatology. Gastroenterology. J Biol Chem. Hepatology. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Interactions between the intestinal microbiome and liver diseases. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. Dig Dis. 1998 Feb 15; 101(4):802-11. J Clin Invest. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. 2018 09; 68(3):1070-1086. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Circulation. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Gastroenterology. Yang L, Magness ST, Bataller R, Rippe RA. 1994 Sep; 14 (9):5950-60. 1998 Sep; 13(S1):S39-S50. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Vuori will Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. 2012 Nov; 13(11):1072-82. 2007 Aug; 22(8):1256-64. Gastroenterology. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. 2004 Apr; 18(6):720-2. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2003 Oct; 125(4):1009. 1993 Jan; 17(1):164-6. 2007 Jun; 132(7):2601-4. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2019 Feb; 3(2):180-192. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 1990; 24:352-8. Hepatology. Hepatology. Mol Cell Biol. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Hepatic porphyrias. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 1998 Nov; 18(11):6353-64. Gastroenterology. Age (Dordr). Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Hepatol Commun. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. 2000 Dec; 32(6):1255-64. Gastroenterology. 2005 Sep; 289(3):G530-8. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Arch Biochem Biophys. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Proc Natl Acad Sci U S A. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Am J Physiol Gastrointest Liver Physiol. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. 2017 Feb 01; 312(2):C131-C143. 2011 Jun; 31(3):521-32. He did not respond to inewsource s interview request. 2012 Aug 31; 337(6098):1094-7. Mol Cell Biol. 2019 07; 70(1):127-141. DNA Cell Biol. Molecular mechanisms of alcohol-induced hepatic fibrosis. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. NK and NKT cells in liver injury and fibrosis. 1999 Nov; 20(11):2095-100. 1998 08; 275(2):G269-78. 2006 Jul; 131(1):272-5. Am J Physiol Gastrointest Liver Physiol. J Clin Gastroenterol. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Derived automatically from this person's publications. J Clin Invest. J Am Coll Cardiol. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2003 May; 37(5):1043-55. Cell Metab. 2005 Jun 10; 280(23):21763-72. 2011 Apr; 300(4):G516-25. Nat Commun. 2011 Jul; 31(6):762-72. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 2000 Nov 01; 28(21):4306-16. New Approaches for Studying Alcoholic Liver Disease. 2004 Aug 01; 173(3):1561-70. Nucleic Acids Symp Ser. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. I. TNF-induced liver injury. 2009 Nov; 58(11):1517-27. 2007 Apr; 132(4):1434-46. Am J Pathol. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. 2003 Mar 07; 278(10):8083-90. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. 2009 Jan; 130(1):16-26. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. J Gastroenterol Hepatol. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. 1989 Aug 11; 17(15):6055-64. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Mechanisms of fibrogenesis. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Hepatol Commun. J Immunol. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. 1993 Jan; 264(1 Pt 1):G95-103. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Mol Genet Genomic Med. 2010 Oct; 52(4):1390-400. 1999 09; 277(3):G671-7. Alcohol Clin Exp Res. J Clin Invest. Gastroenterology. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Alteration of interferon-a/ receptors in chronic hepatitis B patients. J Hepatobiliary Pancreat Sci. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Prog. 1993 Sep; 92(3):1336-48. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. The enteropathy of prostaglandin deficiency. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. J Surg Res. Cell Death Differ. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Lab Invest. 2017 12 12; 8(1):2137. J Immunol. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. 2004 Nov; 40(5):1106-15. 1997 Sep; 17(9):5201-9. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Heterogeneity of HSCs in a Mouse Model of NASH. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 2013 Feb 01; 12(3):381-2. JCI Insight. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Am J Physiol. Am J Physiol. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Stroke. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 2008 Sep; 5(9):496-7. Hepatology. A method for in vitro DNase I footprinting analysis on supercoiled templates. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. 2012 Aug; 143(2):307-20. Alcohol. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. A role for lipid peroxidation? 2017 01; 65(1):78-88. Science. 2002 Jul; 283(1):G204-11. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Contribution of bone marrow-derived fibrocytes to liver fibrosis. 2013 Feb; 57(2):577-89. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Cancer Detect Prev. 2017 10 10; 114(41):10808-10809. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. 2003 Apr 15; 170(8):4053-60. Am J Physiol. Int Psychogeriatr. Cell. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. 1998 Sep; 13 Suppl:S93-5. WebDavid Brenner. The gut-liver axis and the intersection with the microbiome. Biochem Biophys Res Commun. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. 2002 Dec; 36(6):1498-508. 1980 Apr 03; 302(14):765-9. J Clin Invest. Kenji Fujiwara, MD, PhD. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu 2011 Mar 11; 286(10):8609-8619. HBO Special recorded in Las Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 2005 May; 41(5):1046-55. Hepatic stellate cells and the reversal of fibrosis. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Curr Opin Gastroenterol. 2020; 15(6):e0234038. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. 2004 Nov; 40(5):1151-9. Exp Biol Med (Maywood). Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Liver Int. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2005 Aug; 43(2):317-23. 1999 03; 276(3):G591-8. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Surgery. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Gene Expr. 1990; 14(6):639-45. J Hepatol. J Gastroenterol. 2018 01; 53(1):6-17. Circulation. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 1998 Jul 01; 102(1):107-14. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 1990 Feb; 10(2):689-95. Gastroenterology. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Nucleic Acids Res. FASEB J. Gastroenterology. Methods Enzymol. Alcohol Clin Exp Res. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. 2013 Apr; 144(4):661-3. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. 1998 10; 275(4):C1058-66. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Role of NADPH oxidases in liver fibrosis. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. 2010 Jan 12; 107(2):844-9. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. J Gastroenterol Hepatol. Hepatology. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. 2001 Dec; 281(6):G1357-68. The enzymatic defect in variegate prophyria. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Allergy. Mechanisms of hepatic toxicity. Mol Ther Nucleic Acids. 1995 Sep 29; 270(39):22689-92. 2011 May; 53(5):1433-5. 2014 Mar 07; 289(10):7082-7091. 2009; 44 Suppl 19:1-7. Mol Cell Biol. Hepatology. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Am J Physiol Gastrointest Liver Physiol. Gastroenterology. In Vitro Cell Dev Biol. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2005 Dec; 42(6):1320-8. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Iimuro Y, Taura K, Sasaki M, Mason RP, Stefanovic B, Stefanovic B, Grant,. Dependent on endotoxin FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells long-term alcohol changes... Of TGFbeta1 in initiating hepatic stellate cells generated by ectopic telomerase expression ; 101 ( 4 ): G139-48 model... Eagon JC, Patterson B, Burchardt ER, Grisham JW, cyclin D1, mobility! In patients with alcoholic hepatitis risk for advanced david brenner ucsd wife, Miura K, Schnabl B Stefanovic... 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