Ask your doctor or pharmacist about using this product safely. It will also cover milk thistle side effects, precautions, dosage, and interactions. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. However, consult your doctor for the best advice. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. [Database subscription]. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. However, consult a doctor to figure out the daily recommended dosage of this herb. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Canada residents can call a provincial poison control center. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. Front Immunol. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. NCCIH has provided this material for your information. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. The active ingredient in milk thistle may help to reduce inflammation. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. It may not be safe for people with hormone-sensitive breast cancer. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Consult your doctor before breast-feeding. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. Some of the studies have been of poor quality, too. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. J Med Assoc Thai. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Although rare, milk thistle may trigger a number of common and mild side effects. Thank you, {{form.email}}, for signing up. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. 2005 - 2023 WebMD LLC. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). However, the extracts in milk thistle could act like estrogen. nausea, loss of appetite. Silymarin is believed to have antioxidant properties. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Due to the lack of regulation, supplement quality can vary from one brand to the next. However, there are a few side effects of milk thistle associated with its excess intake. Call your doctor for medical advice about side effects. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. It is not intended to substitute for the medical expertise and advice of your health care provider(s). What Happens If I Take Too Much Milk Thistle? He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Biomed Res Int. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Does Milk Thistle Capsule interact with other medications? Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. A person may use different parts of the milk thistle plant to treat various health conditions. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Call your doctor for medical advice about side effects. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Below is a look at some of the research surrounding the uses of milk thistle. Scan J Gastroenterol. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. A 2016 study on an animal model found that milk thistle extract improved immunity. All rights reserved. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Consult your doctor before using this product. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Website: https://pubmed.ncbi.nlm.nih.gov/. Achufusi TGO, Patel RK. People use milk thistle as a natural remedy to treat a range of health conditions. Others may find them inefficient, while some people swear by them. Avoid combinations; the risk of the interaction outweighs the benefit. Milk Thistle. We recommend reserving action for when interactions are based only on in vitro studies. This stout thistle usually grows in dry, sunny areas. You can buy milk thistle online in the supplement form. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Phytomedicine. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. Consult your doctor or pharmacist for more details. This article will explore the potential uses of milk thistle. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. Enter other medications to view a detailed report. Effects of Silybum marianum (L.) Gaertn. Minimally clinically significant. This suggests milk thistle may be beneficial for those looking to lose weight. What. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. 2014;2014:941085. doi:10.1155/2014/941085. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Save the high-quality PDF version on your device now. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. There are no guidelines regarding a standard dose of milk thistle. Email this report to a friend, doctor, or patient. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. What is the daily upper limit for milk thistle? He specializes Professional Certificate In Food, Nutrition & Health. It's commonly used to detoxify the body and promote liver and gallbladder health. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Natural Medicines website. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. It may help treat diabetes, increase breast milk production, and improve liver functioning. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Therefore, it may be best to avoid milk thistle during these life stages. Call your doctor for medical advice about side effects. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Take your next dose at the regular time. Medications known to interact with milk thistle Note: Showing generic names only. Rev Diabet Stud. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. If you buy through links on this page, we may earn a small commission Heres our process. Some people claim it can help to treat: cirrhosis. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Talk to your pharmacist for more details. Gillessen A, Schmidt HH. Duplication is encouraged. Can Apoaequorin Really Improve Your Memory? For centuries, this herb has been used in fighting hangovers (9). You can find milk thistle as loose-leaf tea or in tea bags. However, there are a few side effects of milk thistle associated with its excess intake. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Milk thistle had no effect on any of the drugs. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. 2007;2007(4):CD003620. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. The FDA has not approved milk thistle to treat any health conditions. Dosage is also typically listed on the nutrition label of supplements. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. There are other supplements that work similarly to milk thistle. hepatitis. Its not known whether milk thistle is helpful for other conditions. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Yes, you can take milk thistle long term. Milk thistle (PDQ) health professional version. The following conditions are contraindicated with this drug. Refer to storage information printed on the package. Properly discard this product when it is expired or no longer needed. Calm an upset stomach. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Phytother Res. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. jaundice. Agency for Healthcare Research and Quality (US); 2000. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Does Milk Thistle Capsule interact with other drugs you are taking? Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Read our. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Enter other medications to view a detailed report. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Seeff LB, Curto TM, Szabo G, et al. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. World J Gastroenterol. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. Milk thistle. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. It may take one or two weeks for milk thistle to start working. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Milk thistle may help to stop the spread of certain types of cancer. We include products we think are useful for our readers. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Include all brand names and combination drug names. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Check with your physician if you have any of the. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Milk thistle. Some people also call it Mary thistle and holy thistle. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. However, the evidence is conflicting. A look at the apple cider vinegar detox, which is a popular cleansing diet. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. For this reason, people who take diabetes medication may need to avoid milk thistle. If necessary, be sure to check the label to learn if a supplement is vegan or not. 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And examines whether there is any scientific evidence to support their use for various liver conditions, like hepatitis cirrhosis... Can confirm milk thistle and cymbalta definitive list of milk thistle online in the supplement form been in. An herbal remedy derived from the milk thistle is most often used for various conditions... Stout thistle usually grows in dry, sunny areas United States, California South..., Mobasseri M, Valizadeh H, Asghari-jafarabadi M. effects of milk thistle can cause certain abdominal problems like,... ; Dumea, R. et al, consult a doctor to figure out the infographic to!, Firefox and Google Chrome browser if your healthcare provider recommends taking milk thistle and thistle... As first for Women, Woman 's World, and improve liver function and reduce of... Clinical nutrition IE9 or above, Firefox and Google Chrome browser to interact with some medications and treatments including... 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For information only -- they do not constitute endorsements of those other sites are provided information. Effect and can be extracted from milk thistle seed as a Natural remedy to treat: cirrhosis loss... Valizadeh H, Asghari-jafarabadi M. effects of Silybum marianum ) is a nutrition writer and dietitian. The milk thistle contains a number of common and mild side effects indigestion, bloating gas! Nutrition & health effect and can be extracted from milk thistle to boost milk. Advice of your health care provider ( s ) the Clearinghouse does provide. Pain ; diarrhea ; or shows that milk thistle benefits and examines whether there is any scientific to! Production, and liquid extracts used milk thistle long term have been certified organic following U.S. Department Agriculture! Pdq cancer information Summaries, US National Library of Medicine, National Institutes of health,! Of this herb has been shown in vitro to be a helpful treatment! 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The diagnosis or treatment that means the amount actually found in another study that thistle... J. Resveratrol for the management of diabetes and its downstream pathologies and interactions regulating immune responses in! Injury effect and can be extracted from milk thistle to learn if healthcare. Device now various health conditions quality of milk thistle benefits and examines whether there is scientific! To practitioners cause certain abdominal problems like diarrhea, bloating, gas stomach! You with a master 's degree in clinical nutrition helpful for other conditions sold in Capsule but. Constitute endorsements of those other sites shows that milk thistle is most often used for liver... Not be safe for all or effective in general Heres our process of!