Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. This is worth the cost to buy a six-pack of protection. She does have history of seizures. I am sorry you are going through this! Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. He never ever used to do this. Use topical or a collar if you are concerned. I called my Vet and waited all day for them to call back, useless. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Still waiting to find out of she has progressed. Billy Boy is a 9 week old Daisy Dog. (toy aussie & corgi). I feel like it was a massive overdose. This is still going on weeks later. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. My dog died from it after one dose within 24 hours. Gave my dogs simparica and they both have lost their appetite! Hi, any chance you did a spinal tap? I will post an update 7 days later. Does any one think this could be a reaction to Simparico Trio? Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . His skin became itchy and his eyes were too. Started downhill health issues with initial dose. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. Im convinced the medicine caused this and now she cant walk. I hope it is better. In such cases, please visit the veterinarian as soon as possible. I gave this to my 4 month old puppy and was not told of the neurological side effects. He already has canine dementia on and off. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. Just wondering? First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. We are going back to the Seresto collar next month. In very rare instances, mild side effects and irritations can occur for a short period of time. Then suddenly dog has diarrhea and it lasted for several days. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. On her 3rd round of antibiotics (each a different kind) and completing prednisone. The door is open , its where he prefers to sleep on a doggie bed . It is recommended to wash your hands after administering this medication. Nobody knows what causes it or makes one dog recover and another not. I've read that simparica takes 35 days to get out of their system. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). It's definitely not! I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. I realized he had no control over his body . Gave my 28lb German Spitz her monthly prescibed dose of Simparica. Anything with tick prevention is in the same class of drugs. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. She definitely is not herself and behaving strangely. He isnt losing weight but really looks horrible. These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. All oral tick meds are a risk. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. Or has it been too many doses ? We think that the drug is the cause of the seizures . Hoping for good news with your pup!! This may post twice - I didn't see my original post so I'm trying again! At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. He had it once before with no issues. Anyone else have the same eye issues? The most common side effects of Simparica in dogs are vomiting and diarrhea. We ended up encouraging him to eat something by spoon feeding him. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. At first B seemed fine. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. The issues started within 24 hours of the dose and continue. Will not use this again and will warn others. I would, still boil chicken, carrots, potatoes for his meals. Is it just me or does it seem like everyone is in this together? We had family in for the weekend and he was not himself. Please anyone let me know if there is a class action law suit or where we can start one? After about 35 days he was back to normal. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Was checking out before using . We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). Since then I've researched loads and as you say the FDA put out a report. I am interested in the petition and the company's response. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! Then they come back! I took him to the ER they checked his vitals and sent me home. He is very whinny and is drinking a lot of water. Next she developed severe tremors. Now I am terrified for his well being. If fact it specifically states on the product label "Not for use in humans". I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. after a few months of this i decided to go back to Sentinel and Bravecto. I know it's still in her system because I am still finding dead ticks that I miss because they are the size of a sesame seed. I will never give him this drug again. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! He woke up and seemed much brighter. This seemed like perfect treatment 3 in 1 but at what cost? You keep your dog cages? My one year old has severe diarrhea and is very agitated and anxious. I must admit that I am pretty nervous about it, but we shall see. Chewable tablets can be given directly to your dog or broken up and mixed with food. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. Vet said if she vomits bring her in. She has what is called knuckling. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. What do I do? Omg this is horrible. These dog training tips will help you get started. He has been low energy since. I came across this site and read so much about symptoms that I now realize he has been having. Read package insert - yes was tested on female dogs who were bred. This junk needs to be pulled from the market. He has been drinking more water then usual. He had kidney failure he had seizures he had nervous system problems. She has had tremors, very lethargic, drinking lots of water. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. Im certain that its the simparica. In total we spend around $780 trying to control/stop the tremors & seizures. I've tried Gatorade and Ginger ale but he only drank a little. When I bathe him the scabs fall off and I think, oh good, this problem is going away. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. She keeps running through the house as though looking for something. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. You ask why they are giving this poison to our furbabies, it's easy. No simparica for them either! Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. When did you stop giving the Simparico Trio? Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. Side effects with Simparica are not common. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. I hope yours is an isolated incident! I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. It has been one week and she has been acting very anxious since. Hopefully there are many other dogs that are unaffected, and just aren't written about here. He seems dehydrated. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. I wish every one the best. I just almost had a similar incident with my 16wk cavapoo. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. He also lashes at me with his teeth. Plan to take him to see the vet tomorrow. I took him in today and they think it might be meningitis. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. I gave my black lab mix Simparica for the 1st time on 4/1. Was not too excited about it, and I really should've declined it. They are monitoring her. Simparica Trio is just one of many parasite prevention products on the market for dogs. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. this link is to an external site that may or may not meet accessibility guidelines. Wow. I put him on boiled chicken & rice and got him calmed down. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. I read all the above and it makes me sad. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. The excerpts below from the manufacturers' Prescribing . This crap is poison! Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Overview. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. Anyway, he prescribed him pain relief for 7 days. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. He is not the same puppy prior to two days ago! The king cavalier bichon mix seems to be ok just not eating much if at all. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. Its crazy to think they dont recover and can die in a few months. After I picked her up she just went back down and died on the way back to animal emergency room. They had been given the two pills separately from the breeder but my vet recommended this all in one. I wish I could get this out of her system now. No diarrhea or vomiting or seizures. Hi, my dog is having these same issues right now and Im dying. I gave my 15 year old dog this medicine. What are the side effects of simparica trio for dogs? Hi, Im wondering whats going on with your dog now? Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. Not drinking any water but drooling and swallowing all the time. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. The representative for the company says the half life is 16 days. 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